The students know the structure and function of the components of the immune system and basic mechanisms of the development of immunocompetent cells as well as the foreign / self-differentiation. They understand the applications of immunological analysis methods based on immunological reactions.

None

• Immunological basics: components of the immune system (structure and function of lymphoid organs, characterization and function of the cell system of the immune defense , biochemical structure and function of immune defense, initiation, organization and phases of immune defense, primary and secondary immune response, inflammation, immune mediators, immunological memory);
• Mechanisms of innate immunity (e.g., phagocytosis, burst, acute phase response, inflammation, leukocyte migration)
• Recognition mechanisms (MHCI, MHCII, cell receptors, antibodies and immune reaction, complement system)
• Lymphocyte development (clonal selection, somatic recombination)
• Mechanisms of immune tolerance
• Immune response to specific pathogens
• Basics of immunological analysis methods
• Introduction: definitions, composition and structure of antibodies, antibody classes, antigens, antibody reactions, antibody acquisition, significant parameters of Ag / Ab reactions
• Heidelberger Kendall curve; overview of immunochemical analysis methods: e.g. immunagglutination, immunoprecipitation, immunodiffusion and complement fixation; direct and indirect Ag / Ab detection using selected examples

Bröker B. et al. (2019), Grundwissen Immunologie, Spektrum
Murphy K. & Weaver C. (2018), Janeway Immunologie, Spektrum
Schmetzer O. (2015), Immunologie - Basics, Elsevier;
Rink L. et al. (2015), Immunologie für Einsteiger, Spektrum;
Pezzutto A. et al. (2006), Taschenatlas der Immunologie: Grundlagen, Labor, Klinik, Thieme;
Books, journals and websites according to the current state of knowledge in the respective fields.

Lectures

Module examination